NNRTI & Nucleotide Analogues

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NUCLEOTIDE ANALOGUES +

Nucleotide analogues: Drugs based on nucleotides that are chemically altered to inhibit production or activity of disease causing proteins. Maybe more stable and active than nucleosides.

Drug	Dose	Common Side EffectsComments
Tenofovir Viread	300 mg once daily with food	Generally well tolerated. Active against HBV
Hydroxyurea (not approved for HIV therapy) Hydrea	500 mg twice daily	Bone marrow suppression, aphthous ulcers, hair loss, peripheral neuropathy, hepatotoxicity. Augments ddI and d4T and their toxicities. No direct antiviral effect. Used rarely due to reported toxicity.

[ Nucleoside Analogues ] [ Protease Inhibitors ] [ NNRTIs ] [ Fusion Inhibitors ] [ Nucleotide Analogues ] [ Other Drugs ] [ New Drugs ]

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