| Clinical Stem Cell Transplantation is not then newborn | | | | about 50 countries, and has been featured by first |
| branch of medicine and has already received the first | | | | rank magazines (Sunday Times, Boston Globe, |
| Nobel Prize (1990) for contribution to the "treatment | | | | Spiegel, Max) and TV (ZDF, BBC). |
| of human diseases". | | | | Own EmCell's experience exceeds 5000 FSC |
| Bone marrow was the initial source of stem cells | | | | transplantations for various diseases and conditions. |
| used for clinical application starting from late 1960's. | | | | This is the largest FSC clinical experience in the world |
| Stem cells from dead human fetuses (FSC) were | | | | so far. |
| used for treatment of severe immune and blood | | | | The Guidelines for using FSCT in the treatment of |
| diseases in children and adults starting from 1970's. | | | | several diseases and conditions were developed on |
| Stem cells from cord blood of a newborn were a | | | | the basis of six post-doctoral multiyear Ph.D. studies. |
| good option for treatment of this same person later, | | | | These researches were carried out at the National |
| if needed. All these sources of stem cells are legal for | | | | Medical University and at more than a dozen |
| therapeutic use in most countries (fetal stem cells | | | | reputable medical Institutes of the Ministry of Health |
| – in EU since 1979, in USA since 1994). | | | | and Academy of Medical Science of Ukraine |
| In 1998 viable embryos following artificial in vitro | | | | (1994-2003). The Guidelines were officially approved |
| fertilization were declared a new promising source of | | | | (1999–2001) by the Ministry of Health of Ukraine |
| stem cells. Probably, everybody has heard of the | | | | and Academy of Medical Science of Ukraine. |
| debates on the approval of this source. Well… The | | | | At present, Ukraine apparently has the highest level |
| Medical community has never offered to use viable | | | | of preparedness for wide-scale FSCT clinical |
| embryos – neither fresh, nor preserved, "spare" | | | | application. |
| or "donated" - as a medicine or as a source for | | | | Practical Side of FSC Transplantations The most |
| medicine. | | | | efficient FSCT treatment is related to new-onset |
| Despite this, they might be as good for clinical | | | | diabetes mellitus. |
| purposes as FSC. Pluripotent stem cells that can | | | | All of a sudden a person faints – and shocking |
| develop into cells of the three major tissue types can | | | | news enters the family. Medicine of civilized world is |
| also be derived from this source, as from certain | | | | ready to provide diabetic person with special care. |
| fetal tissue. | | | | But keep in mind. Diabetes mellitus is caused by |
| The research for creation of a robust daily clinical | | | | attack of own immune system against special β-cells, |
| method for FSC continued during 1970's and 1980's in | | | | producing insulin. The first faint happens when about |
| about 20 countries, and multiple study results were | | | | 80% of β-cells are destroyed, and during the nearest |
| published in top medical scientific journals, but failed. | | | | 4-6 months so would be the rest. The remaining |
| Some very good results proved the high curative | | | | 20% would allow healthy life with minor diet |
| potential of stem cells, as phenomena. At the same | | | | limitations. But modern treatment cannot and does |
| time, poor statistic results in groups of patients | | | | not stop this autoimmune aggression. There is no |
| indicated the absence of a reliable technological | | | | means to stop it now; it may be only to retard. |
| solution and the lack of a safe and efficient method | | | | Regular treatment just helps patients to live in |
| for clinical use of FSC. By the late 1980's clinical | | | | absence of own insulin and moderates complications. |
| branch of FSC transplantation (FSTC) was almost | | | | The only known modern method to stop |
| abandoned. | | | | autoimmune aggression is FSCT. Your doctor may |
| The restart of clinical FSCT happened in early 1990's | | | | not be aware of it because the method is rather |
| after Prof. Alexander Smikodub (National Medical | | | | new, as any patented method should be. |
| University, Center EmCell, Kiev, Ukraine) created a | | | | FSCT method for diabetes treatment prevents |
| safe clinical method for FSCT with stable clinical | | | | further destruction of β-cells and allows avoiding |
| results. | | | | development of diabetes mellitus according to regular |
| And what was the stunning benefit – this | | | | scenario. This is a real breakthrough. |
| method allowed transplantation without rejection of | | | | The most grateful patients for FSCT are elderly |
| transplants in absence of immune suppression! | | | | people.Being transplanted, stem cells spread with |
| The method allowed avoiding histocompatibility barrier | | | | blood current all over the body. They try to find a |
| instead of crushing it, like in organ and bone marrow | | | | place to live. A huge oak prevents other trees from |
| transplantation (by means of conditioning and immune | | | | living nearby. So a healthy function or tissue would |
| suppression). Among all stem cells, only certain FSC | | | | not allow living of a foreign cell on its territory. |
| allow for transplantation without rejection and with | | | | Healthy young person would feel no action of FSCT |
| no immune suppression required. | | | | at all. |
| This was the fulfillment of an unbelievable dream of | | | | In this regard, you may understand all the attraction |
| transplantology – the host totally accepts the | | | | of an elderly person for transplanted stem cells. |
| transplant! No rejection, no crisis, no conditioning | | | | There is plenty of space within faded tissues to live |
| disabling immune system of the host, no life long | | | | and to reveal the best features. For an elderly person |
| immune suppression needed, and no weakened | | | | it means thorough reparation of all faded tissues and |
| immune protection against infection and cancer. | | | | many functions. Elderly person has no need to |
| In 1998 the first US patent for FSC treatment of | | | | complain or describe what is wrong. Stem cells would |
| HIV/AIDS was granted to EmCell (Kiev, Ukraine). | | | | find and inhabit all weakened places by themselves. |
| Several Patents (Ukraine, US, EC, Russia) were | | | | Typical duration of curative effects is 2-3 years, |
| granted during 1996-2002 for treatment of Diabetes, | | | | repeated FSCT are allowed and give more long-term |
| AIDS, and some other diseases. | | | | effects. |
| First, we treated patients with severe hematological | | | | The most crucial circumstances, when FSCT may |
| diseases, immunodeficiency, and Diabetes Mellitus. | | | | really save life, are related to conditions of anemia, |
| Then indications for FSCT became more and more | | | | especially, after chemotherapy. |
| widespread. The procedure of FSCT was refined. | | | | In chemotherapy, there is a fine balance. |
| At the 4th Congress of the International Cell | | | | Chemotherapy, to be efficient in killing more cancer |
| Transplant Society in 1999 (Montreux, Switzerland) all | | | | cells, should be aggressive. Aggressive therapy is |
| five reports on clinical use of FSCT were presented | | | | risky for the patients' life. |
| by Cell Therapy Clinic of National Medical University | | | | In most cases of strong suppression of hemopoiesis |
| and Center EmCell, Kiev, Ukraine (since 1994). | | | | after chemotherapy FSCT allow recovery of blood |
| As well as the only clinical report on treatment with | | | | count within 5-7 days (!) and provide two-threefold |
| the use of FSCT at the First European Conference | | | | reduction of quantity of infectious and hemorrhage |
| on Cellular Therapy in Pasteur Institute in Paris (2000). | | | | complications. So, chemotherapy with FSCT at hand |
| EmCell has thus far contributed to nearly 40 | | | | can be more aggressive, efficient and on the other |
| international conferences, accepted patients from | | | | hand even more safe and easier to endure. |